Abstract
Allogeneic hematopoietic cell transplantation (HCT) is a potential cure for patients with peripheral T-/NK-cell lymphomas (PTCL), but its application is understudied. This prospective trial evaluates a unique reduced-intensity (RIC) transplantation platform in 31 patients with PTCL (NCT03922724). One-year progression-free survival, the primary endpoint, is 53% (95% CI 29-72%) on the RIC arm and 60% (95% CI 25-83%) on the modified-RIC arm. The 3-year overall survival is 61% (95% CI 42-76%), with relapse estimated at 18% (95% CI 6-34%) at 3 years. Transplant-related mortality was 24% (95% CI 10-41%) at 1-year, low at 11% (95% CI 2-29%) for patients ≤60 years but 56% (95% CI 17-82%) for patients >60 years, p = 0.01. There was no grade III-IV acute graft-versus-host disease, while chronic graft-versus-host disease was estimated at 23% (95 CI 10-38%) at 2 years. This study demonstrates a benefit regardless of pre-transplantation disease status, challenging the requirement of remission for HCT.
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Acknowledgements
This work was supported by funding from the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research and a2022 Conquer Cancer Fundable Young Investigator Award, peer-reviewed and determined as fundable but not funded by Conquer Cancer, funded by the National Cancer Institute. The authors would like to thank the inpatient and clinic staff who cared for the patients, as well as the patients and their families.
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Rechache, K.A., Nunes, N.S., Sponaugle, J. et al. Allogeneic hematopoietic cell transplantation in mature T- or NK-lymphomas: a phase II clinical trial. Nat Commun (2026). https://doi.org/10.1038/s41467-026-71461-5
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DOI: https://doi.org/10.1038/s41467-026-71461-5


